11/11/2023 0 Comments Principle of intervention originIf an intervention is truly effective (truth), an intention-to-treat analysis will provide an unbiased estimate of the efficacy of the intervention at the level of adherence in the study. The risk of bias is increased whenever treatment groups are not analyzed according to the group to which they were originally assigned. This method preserves the benefits of randomization, which cannot be assumed when using other methods of analysis. This method allows the investigator (or consumer of the medical literature) to draw accurate (unbiased) conclusions regarding the effectiveness of an intervention. Intention-to-treat analysis is a method for analyzing results in a prospective randomized study where all participants who are randomized are included in the statistical analysis and analyzed according to the group they were originally assigned, regardless of what treatment (if any) they received. Excluding patients from the analysis who violated the research protocol (did not get their intended treatment) can have significant implications that impact the results and analysis of a study. However, patients in clinical trials do not always adhere to the protocol. Knowing the effect the intervention has on patients in clinical trials is critical for making both individual patient as well as population-based decisions. Clinicians, institutions, and policy makers use results from randomized controlled trials to make decisions regarding therapeutic interventions for their patients and populations.
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